The 28-year-old rapper needed nine stitches to a wound above his left eye after he fell at a skateboard park in St. Louis.
He was taken to the DePaul Health Center by his entourage and later took to his twitter page to reveal the cut was a "gnarly" one.
He tweeted: "The Lou was good but I busted my fuggin head at the sk8park! 9stitches! Gnarly gash over my left eye! Luv the people. (sic)"
The hip-hop star had been in the Midwestern city to perform at the Verizon Wireless Amphitheatre outdoor stadium.
The skateboard injury ends an eventful few days for Wayne, who last week was attacked with pepper spray.
The 'Lollipop' rapper and his crew were targeted by a man who put the debilitating substance into the air ducts of Montreal club La Mouche, where the hip-hop star was hosting an after-party following his gig at the Bell Centre last Wednesday night (17.08.11).
The ventilation system was compromised following the stunt, which meant everyone inside the club had to be evacuated.
Luckily, Wayne was "OK" and unaffected by the pepper spray.